Location: US 54 and US 60, Guadalupe Cty Reassurance shield for US 60 as it joins US 54. Location: US 54 and US 60, Guadalupe Cty Followed by a reassurance shield for US 54. Location: US 54 and US 60, Guadalupe Cty Just after 60 and 54 join up, they’ll pick up US 285 as … Continue reading U.S. Route 60, US-54 to US-285